The Sensetivity of Liver, Kidney Andtestis of Rats to Oxidative Stress Induced by Different Doses of Bisphenol A

Bisphenol A (BPA) is a world wide used endocrine disruptor that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of such substances. The aim of the present study is to evaluate the extent to which BPA can affect the liver, kidney and testis by measuring the oxidative stress induced by two different doses of BPA in these organs. Adult male rats were subjected to different oral doses of BPA (25 mg/kg for 6 weeks and 10mg/kg for 6 and 10 weeks, 5 days a week). The oxidative stress arising from BPA was evaluated in liver, kidney and testis tissues. In addition, serum uric acid level as a marker of kidney function together with the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as markers of liver function were measured. The results of the present study showed significant changes in the antioxidant mechanisms in the liver and testis with the high dose of BPA (25 mg/kg). The low dose showed significant changes after 10 weeks in the case of the liver and 6 weeks in the case of the testis. In addition, significant increases in serum uric acid level were observed after the administration of the two doses of BPA for 6 weeks and in AST and ALT activities after the high dose (25 mg/kg). It could be concluded that BPA-induced toxicity is mediated by oxidative stress which was prominent in liver and testis after the short and long term exposure to both the high and low dose.